do polygenic risk scores improve cardiovascular risk prediction

Nontraditional Risk Factors in Cardiovascular Disease Risk Assessment: A Systematic Evidence Report for the U.S. Preventive Services Task Force [Internet]. 2019;73:e285–350. Epub 2012 Jun 12. Polygenic scores, risk and cardiovascular disease examines the current evidence and readiness for clinical implementation of polygenic scores from the perspective of cardiovascular disease prevention. Piepoli MF, Hoes AW, Agewall S, et al. Circ Res. 2019;177:132–45. Get the latest public health information from CDC: https://www.coronavirus.gov. Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting.

Amongst the 270,254 individuals contributing to the analyses, with a median of over 8 years of follow-up, 12,407 incident AF cases were identified using hospital episode statistics and death registry data. ... Consortium, SIGMA Type 2 Diabetes ConsortiumMultiethnic polygenic risk scores improve risk prediction in diverse populations. Read your latest personalised notifications. Malik S, Zhao Y, Budoff M, Nasir K, Blumenthal RS, Bertoni AG, Wong ND. Hindy G, Aragam K, Chaffin M, et al Integration of a genome-wide polygenic score with ACC/AHA pooled cohorts equation in prediction of coronary artery disease events in >285,000 participants. A Journey through Genetic Architecture and Predisposition of Coronary Artery Disease. Samani NJ, Erdmann J, Hall AS, et al; WTCCC and the Cardiogenics Consortium. Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, et al.

2020 Aug 18;76(7):797-808. doi: 10.1016/j.jacc.2020.06.037. A polygenic risk score (PRS) is a quantitative tool to predict an individual's genetic predisposition of developing a disease or a given trait. 2012 Aug;223(2):421-6. doi: 10.1016/j.atherosclerosis.2012.05.035. The findings from this study indicate that an AF PRS can materially improve risk prediction over conventional risk factors. Here, we provide a short overview of the current research related to the possible application of PRS in clinical routine and critically discuss existing pitfalls, which still limit a widespread utility of PRS outside a research setting. By using our site, you acknowledge that you have read and understand our Privacy Policy 2016;37:2315–81. Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A, et al. A polygenic risk score (PRS) was constructed based on 142 independent genetic variants previously associated with AF in a meta-analysis from the AFGen Consortium. The performance of the polygenic risk score was compared with that of the 2013 American College of Cardiology and American Heart Association pooled cohort equations. Weights were based on an international genome-wide association study. Circulation. Dr Wang reported receiving personal fees from Novartis. part may be reproduced without the written permission. Jia X, Al Rifai M, Liu J, Agarwala A, Gulati M, Virani SS. Your email address is used only to let the recipient know who sent the email. 2013. The number of events differs from those in the main analyses because the table is restricted to events occurring over the first 10 years of follow-up. Epidemiol., 41 …
This report provides an overview of the current state of cardiovascular disease prevention, and considers the evidence for the implementation of polygenic scores for cardiovascular disease. Independently of the clinical score, the PRS was associated with a ~50% higher risk of AF per SD (HR 1.57; 95% CI 1.54–1.59) and a 2.5-­fold higher risk (HR 2.59; 95% CI 2.47–2.71) when comparing those in the top vs. the bottom third of the PRS. NIH Abdulrahim JW, Kwee LC, Alenezi F, Sun AY, Baras A, Ajayi TA, Henao R, Holley CL, McGarrah RW, Daubert JP, Truby LK, Vemulapalli S, Wang A, Khouri MG, Shah SH. | Cookies, Polygenic scores and their applications in health, An overview of the epidemiology and risk factors of cardiovascular disease, Risk prediction models and prevention methods in current use for cardiovascular disease, Ongoing developments in, and the readiness for clinical implementation of polygenic scores for cardiovascular disease, A detailed assessment of the clinical utility of using polygenic scores as part of an integrated risk tool for cardiovascular disease. Epub 2020 Sep 22. You can think of it as a snapshot of an individual's genetic "baseline" risk that can predict the probability of future health outcomes. Clin Chem. This document is subject to copyright. by Matt Batcheldor. 2019 May;65(5):609-611. Damask A, Steg PG, Schwartz GG, et al; Regeneron Genetics Center and the ODYSSEY OUTCOMES Investigators. Study finds few meet criteria for healthy cardiovascular lifestyle, Study finds menthol cigarettes do not further increase smokers’ cardiovascular disease, stroke risk, Study shows presence of any calcified plaque significantly raises risk of heart disease for people under age 50, Researchers chart new informatics path in tracking disease risk, Journal of the American Medical Association. The researchers found that the polygenic risk score was associated with 10-year coronary heart disease incidence in both studies (hazard ratio per standard-deviation increment, 1.24 and 1.38 for ARIC and MESA, respectively); however, the addition of the polygenic risk score did not improve the predictive ability of the pooled cohort equations for either study. Circ Genom Precis Med. Int J Epidemiol. 2019;140:A16565. Genomewide association analysis of coronary artery disease. 2019;321:1820–1. These variants can be combined into a polygenic risk score that captures part of an individual’s susceptibility to diseases. Exposures: We are also a registered company no. JAMA. Hindy G, Aragam KG, Ng K, Chaffin M, Lotta LA, Baras A; Regeneron Genetics Center, Drake I, Orho-Melander M, Melander O, Kathiresan S, Khera AV. Lo Sardo V, Chubukov P, Ferguson W, Kumar A, Teng EL, Duran M, et al. J Med Genet. What are polygenic scores and why are they important? Phys.org internet news portal provides the latest news on science, Tech Xplore covers the latest engineering, electronics and technology advances, Science X Network offers the most comprehensive sci-tech news coverage on the web. At the 10-year risk threshold of 7.5%, the addition of the polygenic risk score to the pooled cohort equations did not provide significant improvement in reclassification in either ARIC (NRI, 0.018, 95% CI, -0.012 to 0.036) or MESA (NRI, 0.001, 95% CI, -0.038 to 0.076). Coronary heart disease genetic risk score predicts cardiovascular disease risk in men, not women. The potential of polygenic scores to improve risk stratification has reignited enthusiasm around the use of genetic information to help predict and prevent common disease. Mosley JD, Gupta DK, Tan Jet al. Correspondence to The researchers found that the polygenic risk score was associated with 10-year coronary heart disease incidence in both studies (hazard ratio per … Cardiovascular Drugs and Therapy

Patients with high genome-wide polygenic risk scores for coronary artery disease may receive greater clinical benefit from alirocumab treatment in the ODYSSEY OUTCOMES trial. Unveiling the role of the most impactful cardiovascular risk locus through haplotype editing. Dr Post reported receiving grants from NIH.

Immediate online access to all issues from 2019. 2017;135:2091–101. Your opinions are important to us. Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease (CHD) screening. Curr Opin Lipidol. In this analysis of 2 cohorts of US adults, the polygenic risk score was associated with incident coronary heart disease events but did not significantly improve discrimination, calibration, or risk reclassification compared with conventional predictors. Science. Background. Learn more about Institutional subscriptions. Please enable it to take advantage of the complete set of features! JAMA. https://doi.org/10.1007/s10557-020-07105-7, DOI: https://doi.org/10.1007/s10557-020-07105-7, Over 10 million scientific documents at your fingertips, Not logged in Wolfgang Koenig. Eur Heart J. Neither your address nor the recipient's address will be used for any other purpose. Fox KA, Carruthers K, Steg PG, Avezum A, Granger CB, Montalescot G, et al. 2010;376:1393–400. "Genetics is an important determinant of familial diseases and a key tool for understanding human biology, and the idea that genetics may also be important for predicting common diseases has been a source of excitement over the past several years. Improvement in risk prediction of atherosclerotic cardiovascular disease (ASCVD) using information on the genetic predisposition at an individual level might offer new possibilities for the successful management of such complex trait. Improvement in risk prediction of atherosclerotic cardiovascular disease (ASCVD) using information on the genetic predisposition at an individual level might offer new possibilities for the successful management of such complex trait. external icon Janssens ACJW, Joyner MJ. The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology. Inouye M, Abraham G, Nelson CP, et al; UK Biobank CardioMetabolic Consortium CHD Working Group. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Wünnemann F, Sin Lo K, Langford-Avelar A, et al. Schunkert H, König IR, Kathiresan S, et al; Cardiogenics; CARDIoGRAM Consortium. 2017 Dec 1;2(12):1332-1340. doi: 10.1001/jamacardio.2017.4191. Department: University of Hong Kong.


2016;375:2349–58.

Lancet. PubMed Central 

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