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.It is also useful in organic chemistry for the test of alcohols and carboxylic acid. Synthesis of Aspirin By: Jon Torre Purpose: To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid (1) to form acetylsalicylic acid (2). It should be noted that ester formation cannot occur in the presence of base, only acid. A percent yield that is more than 100 means that you have more than what you were supposed to get. 3 to 4 drops of conc. Aspirin is a drug that is usually used to relieve minor aches and pain and other medical uses such as anti-inflammatory medication. endobj The major experimental findings are that, accuracy and attentiveness is very important in this experiment to obtain aspirin that is pure. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. The theory melting point is 140 ÌŠC and the experiment melting point range is 134.2 ÌŠC to 136.1 ÌŠC. The objective of this experiment is to enable us to conduct the synthesis of aspirin, reinforce the skills of recrystallisation and reinforce the technique of melting point determination. The % yield was calculated and the purity of the aspirin was tested with ferric chloride. �qeI����% Any names, logos, brands, and other trademarks or images featured or referred to within the UHScienceResource.com website are the property of their respective trademark holders. Aspirin Synthesis and Analysis Revised: 12/13/14 • Crush an aspirin tablet and place in a labeled, pre-weighed vial or test tube. Looking for a flexible role? The lab manual will have all the experiment procedures you will be performing during the semester including their respective datasheet and postlab questions. Number of moles = mass of substance ÷ molar mass of substance, Synthesis Reactions of Aspirin and Methyl Salicylate (click to enlarge). Reference this. There were some experimental errors that have caused variation in my results compared to the theoretical solutions. It is reversible reaction and they product sweet smelling products. We're here to answer any questions you have about our services. Additional 40mL of cold water is added. Reactions: Procedure and Results: Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. The active ingredient of the drug Aspirin, acetylsalicylic acid can be synthesized through an esterification reaction between salicylic acid and acetic anhydride. It is carried out to form ester from an acid and an alcohol. Registered Data Controller No: Z1821391. This lab will require you to calculate the percent yield of the aspirin synthesis. This reaction is the reverse of the synthesis reaction. discovered in 1897 by Felix Hoffman, it has since been used in over 50 over-the-counter medicines. Synthesis of Aspirin is known as esterification. This website is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon properties. The information provided below are things you will need to know and understand to complete this experiment successfully. The purpose of this lab is to synthesize and characterize high purity aspirin. The maximum allowable amount of Disclaimer: This work has been submitted by a university student. However, the low percent yield can also mean that the reactant has not reacted completely or the reaction is not complete. Hence this might have affected the percent yield too. Remember, the information given by TA should have the highest importance and supersedes all information provided on this page. Sulphuric acid is added and heated for a short period to complete reaction. A percent yield that is less than 100 means that you made less than what you were supposed to get. A lab coat is required and must be worn once lab begins. Warmed. Reactions: Procedure and Results: Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. It is used in polymer industry. Part C is dependent on how fast you can complete part A since it requires the sample yielded to analyze. The synthesis of aspirin is a multi-billion dollar a year chemical. As we have to wash down the crystals before we carry out the suction filtration, some crystals might have dissolved. Start studying Synthesis of Aspirin and Other Esters. The maximum allowable amount of The hydroxyl group on the salicylic acid is the site of esterification. stream This expected value will be compared to the amount obtain from your experiment to calculate percent yield. Major Chemical Concept. You will then use correct technique to note the odor. Acetic anhydride is uses as it is cheap and forms a by-product, acetic acid which is not corrosive and can be recovered to make more acetic anhydride unlike other acetylating agents that also can be used. The synthesis of aspirin is known in organic chemistry as an esterification reaction. However, you may find these cheaper on sites like Amazon (links below). stream Aspirin is a derivative of salicylic acid that is a mild, nonnarcotic analgesic useful in the relief of headache and muscle and joint aches. Synthesis of Esters Lab Report GSEs: Science Process Skills 2:11:5.5 Students will discover how the composition of a molecule affects its interactions with other molecules. From both the calculations, I can evaluate that the aspirin is pure to a large extent however due to some errors or improper techniques; the percent yield is not up to expectation and incomplete reactions might also be one of the reasons. These will be needed to determine the expected number of moles of aspirin (1:1) which will be used in your percent yield calculations. It is the addition of water when carrying out suction filtration. Then, determine the melting point of aspirin using necessary apparatus. Free resources to assist you with your university studies! Using one three test tubes, you will mix combine ethanol and Iron(III) chloride to each. The % yield of the aspirin was 132%. Phenols react with ferric chloride to produce, a purple compound. You will then add salicylic acid to one and your synthesized from Part A in another test tube. Remember, the lab may change or be modified from semester to semester! xڽ}M��q�=E�f`+�?�@�#�5�DI/�����A��Y��׫��+�:=��`%3�naz��2#=<<����*�jB^���1Z�WWV|��n�������?��]��뷫�������+�����ߙ��.�w?Q��ê�P�����r>�l�qi��R�����c;��m��_~&N�`F��O��u|�Ϗݕ`��_y�_q��3��+a��x|ez���A(��A�Y^�^1OW�%O'�Ȯ��=73_����d����^O�z���W���a���w����nq�N��b����������Ǖ[�iE^���'���qm+lÜw��Gw���%��j��.8뎞��J��͇�Z�F���J,G�zqE����Jp���?�W�?Z�z%�p��劉q�>���w�k4����1�v�y��Ă3�է�[��[�X�����>��O���9���PP�P�8H'���!\¾��W�"���㜽. The aspirin crystals are packed into the small capillary tubes and make sure they are all compressed without air gaps. Percent yield is calculated by (Mass of dried, recrystallised aspirin) ÷ (Expected mass of aspirin). This experiment can be completed relatively quickly. 4 0 obj Measure out ~3 g of salicylic acid on an analytical balance, recording its mass to the nearest 0.001 g. Transfer the salicylic acid into a second 125-mL Erlenmeyer flask (not the one with the water in it), and record the mass of the salicylic acid on your report sheet. ��_�����߳/�(�>�w����Q�}�����{����=��'9ޑ\%]��W�d ��U\E��{�� ?�).�a�� �q�L���+EY��@I�4��� N The main procedures are preparation of aspirin, recrystallisation of aspirin and lastly determining the melting point of the aspirin. %PDF-1.3 The ferric chloride test was performed to, determine the purity of the lab made aspirin. During this process, there were some crystals that got blown away by the wind and some crystals poured on the desk too. compare the polarity of other components of the reaction (salicylic acid and crude product)3. Synthesis of Aspirin … Third, we will produce an ester. Disclaimer: none of those involved with this website, in any way whatsoever,  can be responsible for your use of the information contained on these webpages or those linked. If solid separates, warm till solid dissolved completely. Specifically, General Chemistry Laboratories A Freshman Workbook. Once solid dissolved, weigh the watch glass and filter paper, use the filter paper to carry out suction filtration, place crystals on watch glass, weigh the dried crystal and calculate the weight of the aspirin. All addition of chemicals to aspirin is done in the fumehood. acid or aspirin. Level. ;��. Science Process Skills 4:12:2.2 Students will create written reports and journals to share and This part will have you analyze your synthesis of aspirin from part A. This can be seen from the calculation made based on my experiment using this formula. You can view samples of our professional work here. <> The three main purpose of the fumehood are as follows: In the results, we calculate the percent yield and the melting temperature. 2.4g of salicylic acid is measured in a 100ml conical flask and is recorded. <> Salicylic acid is a derivative of phenol. The purpose of this lab is to synthesize and characterize high purity aspirin. Sign up to receive new content and updates from UH Science Resource. The aspirin made in lab was more pure, than the store bought aspirin rather than the salicylic acid when the ferric chloride test, An ester can be made from an acid anhydride and an alcohol, which is called an, esterification reaction. Crude product collected was dissolved in approx 5mL of ethanol in a 100mL conical flask. Use of them does not imply any affiliation with or endorsement by them. The aspirin synthesized in this experiment will be crystallized from solution. Weight is recorded. Hence, due to the pressure, the filter paper tore and our crude product entered the filter flask that was containing the impurities and other liquid. Percent yield is calculated by dividing your actual yield (mass of aspirin you made) with the expected or theoretical yield (mass you calculated) multiplied by 100. Part B. Weight of the dried, recrystallised aspirin, the expected yield of aspirin from the amount of salicylic acid, the percentage yield of dried, recrystalllised aspirin is measured. Biology If you need assistance with writing your essay, our professional essay writing service is here to help! Record the mass of the aspirin tablet.

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